9th Scientific BIOCAPS seminar: Discovery of targets for therapy: the case of aldo-keto reductases

The Institute of Biomedical Research of Vigo (IBIV), under the auspices of the BIOCAPS project (Biomedical capacities support program, 7th REG-POT project) organizes the Seminar "Discovery of targets for therapy: the case of aldo-keto reductases", which will take place on December 19th 2014 at the Experimental Sciences Building, in the Lagoas Marcosende Campus of the University of Vigo.

The focus of the seminar is the role of aldo-keto reductases (in particular AR and AKR1B10) in biology and the approaches to the modulation of their biological activities (primarily in cancer). Structure-based drug design will be discussed as a rational approach to novel modulators, using AKR-ligand complexes resolved by X-ray crystallography and Molecular Dynamics MD in advance of chemical synthesis and in vitro testing using biochemical assays cell lines used to study the potential of AKR as therapeutic target.

Registration for attendance is mandatory and availabe until December 16th, 2014. Free registration here.